03/21/2025
Research Article
How do worms navigate based on learned experience? Kevin Chen, Anuj Sharma, Jonathan Pillow and Andrew Leifer reveal the flexible behavioral strategies and distributed neural computations that underlie learning-dependent odor navigation in Caenorhabditis elegans.
Image credit: pbio.3003005
Current Issue February 2025
03/20/2025
Research Article
Sleep is known to support memory; however, Sheng Huang, Chengji Piao, Stephan Sigrist and colleagues identify an instance where memory hyperfunction may actually provoke sleep deficits. They find that the short-sleep Drosophila mutant, insomniac, has enhanced memory and that PKA signaling balances sleep and memory in these flies.
Image credit: pbio.3003076
03/18/2025
Short Reports
Understanding the consequences of past conservation efforts is essential to inform how we maintain and restore species. An analysis of IUCN Red List data on 67,217 animal species, by Ashley Simkins, Silviu Petrovan and co-workers, reveals that a range of different conservation actions have successfully conserved species that are at greatest risk of extinction, but have rarely resulted in full recovery.
Image credit: BR Ansil
03/17/2025
Short Reports
The secretion mechanisms of many type VI secretion system (T6SS) effectors in Gram-negative bacteria remain unclear. Chaya Mushka Fridman, Eran Bosis, Dor Salomon and colleagues identify a new class of T6SS effectors which can harbor either one or two toxic domains and use WHIX as a secretion motif.
Image credit: pbio.3003053
03/12/2025
Primer
The diversity of bright colors observed across the animal world are often used during mate choice. Richard Merrill explores a new study in PLOS Biology which reveals genetic and neural mechanisms contributing to the evolution of visual mating decisions in Heliconius butterflies.
Image credit: pbio.3003054
03/11/2025
Research Article
Transcription is known to tightly regulate gene expression profiles in stem and differentiating cells, but what about translational control? Ruoxu Wang, Marc Amoyel anc co-workers reveal that signals from the stem cell niche induce changes in translational rates, regulated via eIF3d1 phosphorylation, to control stem cell fate in the Drosophila testis.
Image credit: pbio.3003049
03/19/2025
Community Page
Multiplexed imaging is a powerful approach in spatial biology. This Community Page presents the IBEX Knowledge-Base, a central resource for reagents, protocols and more, to enhance knowledge sharing, optimization and innovation of spatial proteomics techniques.
Image credit: pbio.3003070
03/18/2025
Perspective
This article outlines how collections of microbial isolate from insect vectors aid in identifying microbial targets, and why their implementation must rely on coordinated international efforts that are ethical and ensure equitable benefit sharing.
Image credit: pbio.3003078
03/18/2025
Essay
Sui Huang, Ana Soto and Carlos Sonnenschein explore cancer omics data that challenge the somatic mutation theory, and present theories based on gene regulatory networks and tissue fields that help explain inconsistencies in the data.
Image credit: pbio.3003052
02/28/2025
Perspective
A major challenge in natural-product-based drug discovery is the identification of gene clusters most likely to specify new chemistry and bioactivities. This Perspective discusses the state of the art of antibiotic discovery.
Image credit: pbio.3001026
Neurotechnology offers unprecedented opportunities to treat neural disorders, restore brain function and enhance cognitive abilities. This collection explores the present and possible futures of neurotechnology to improve human health and cognition.
Translating conservation and biodiversity research from the field into the real world is a complex problem. This collection discusses issues around economics, policy, and how to do research that answers questions that decision makers have.
Symbiosis research has become a holistic and pervasive field with a mature theoretical basis. This collection showcases symbiotic relationships across the tree of life, exploring their evolutionary basis and underlying mechanisms.
PLOS Biology is 20 and we are celebrating with a collection that contains articles that look back at landmark studies that we published, others that look past and future, and others discussing how publishing and open science have evolved and what is to come.
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This collection explores engineering strategies to help us adapt plants to a changing climate, including breeding techniques, genome engineering, synthetic biology and microbiome engineering.
March 24 - 27
Meet Senior Magazine Editor Daniel Routledge (droutledge@plos.org)
March 27 - 30
Meet Senior Editor Christian Schnell (cschneill@plos.org)
April 2 - 4
Meet Senior Editor Richard Hodge (rhodge@plos.org)
April 3 - 4
Meet Senior Editor Luke Smith (lsmith@plos.org)
April 6 - 11
Meet Associate Editor Melissa Vazquez Hernandez (mvazquezhernandez@plos.org).
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